Feed-grade Zinc Oxide ZnO Used to Control Diarrhea in Piglets
Recently, the EU proclaimed new sanctions on Russia, including coal, timber, rubber, cement, and fertilizer, as well as high-end seafood zinc oxide.
Zinc oxide is an oxide of zinc. Insoluble in water, soluble in acids and strong bases. Zinc oxide is mainly used in chemical industry, pharmaceutical industry, agriculture and other fields.
Feed-grade zinc oxide has a significant effect on the safe control of piglet diarrhea. However, zinc oxide will also cause rough coat of piglets, unbalanced absorption of trace elements, late growth retardation, environmental pollution and other problems. Therefore, feed-grade zinc oxide is a double-edged sword in controlling diarrhea in piglets.
Zinc oxide does have a good effect on controlling diarrhea. But zinc oxide as an amphoteric oxide, first of all, more than 70% of zinc oxide in gastric acid can not pass safely in the form of functional molecular state ZnO, and is transformed into Zn2+ which has no diarrhea control effect. Not to mention the destruction of bile and small intestinal fluid in the intestine. This is an important reason why a large amount of zinc oxide must be added to ensure that enough ZnO reaches the intestinal tract to play a role and achieve a good diarrhea control effect. For those dissolved Zn2+, will be over-absorbed, high blood zinc concentration, resulting in adverse effects on piglet coat color, growth speed and immune function.
So how to maximize the efficacy of zinc oxide, let the zinc of 1500ppm (based on zinc) play the role and effect of 3000ppm under conventional conditions, so that zinc oxide is not destroyed by digestive juices such as gastric acid, and exists and evenly dispersed in the intestinal tract in the form of molecular ZnO in its effective form?
How to deal with it?
Acid resistance, compatibility with chyme and lipophilicity are the decisive factors that determine whether zinc oxide can maximize the effect of antidiarrheal convergence. Only when zinc oxide is acid-resistant, can it not be neutralized by gastric acid, and can it reach the intestinal tract with molecular zinc oxide particles that can control diarrhea; only when zinc oxide is compatible with chyme can it be rapidly and uniformly dispersed in the intestinal tract and form a uniform protective film on the surface of the entire intestinal mucosa; only when zinc oxide is lipophilic, it can be in close contact with the intestinal mucosa of lipids and enrich to the surface of the intestinal mucosa, and the effect will be better.
How to treat zinc oxide with acid resistance? How to make zinc oxide disperse evenly in the intestines? How to make zinc oxide in close contact with intestinal mucosa? It is a problem that the manufacturer needs to solve.
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The current international situation is highly uncertain, and its economic impact has not been able to be assessed properly. In addition, rising energy and commodity prices and supply chain disruptions are expected to push the price of the zinc oxide higher.